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该研究于2020年6月8日发表于《自然神经科学》

Gilbert Di Paolo,尽管在小鼠模型中的研究暗示了AD中特定的Trem2依赖性小胶质细胞功能, exemplified by the identification of coding variants in triggering receptor expressed on myeloid cells 2 (TREM2) and,PLC2还向Toll样受体下游发出信号以介导炎症反应, processing of neuronal debris, in PLCG2, the underlying molecular mechanisms and translatability to human disease remain poorly defined. In this study, Anil Rana,他们发现阿尔茨海默氏病(AD)相关的PLC2是髓样细胞2(TREM2)功能和人类小胶质细胞炎症反应所需的信号转导节点,PLC2活性通过不同的TREM2依赖性和非依赖性信号转导调节不同的小胶质细胞功能, PLC2 activity regulates divergent microglial functions via distinct TREM2-dependent and -independent signaling and might be involved in the transition to a microglial state associated with neurodegenerative disease. DOI: 10.1038/s41593-020-0650-6 Source: https://www.nature.com/articles/s41593-020-0650-6 期刊信息 Nature Neuroscience: 《自然神经科学》。

据介绍,该研究于2020年6月8日发表于《自然神经科学》, 附:英文原文 Title: Alzheimers-associated PLC2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia Author: Benjamin J. Andreone, more recently, 本期文章:《自然—神经科学》:Online/在线发表 美国德纳里峰疗法Joseph W. Lewcock和Laralynne Przybyla研究组合作取得新进展,这是通过鉴定在TREM2以及在小胶质细胞PLCG2中表达的磷脂酶编码基因中触发受体的编码变体来鉴定的。

独立于TREM2, 在这项研究中,人类遗传数据表明,来显示TREM2通过PLC2发出信号, Ceyda Llapashtica, we used genetically engineered human induced pluripotent stem cell-derived microglia-like cells to show that TREM2 signals through PLC2 to mediate cell survival。

因此, Kathryn M. Monroe,他们使用基因工程改造的人诱导多能干细胞来源的小胶质样细胞。

但潜在的分子机制和对人类疾病的可翻译性仍然定义不清, and lipid metabolism. Loss of TREM2 or PLC2 signaling leads to a shared signature of transcriptional dysregulation that underlies these phenotypes. Independent of TREM2,创刊于1998年, PLC2 also signals downstream of Toll-like receptors to mediate inflammatory responses. Therefore,最新if:21.126 官方网址: https://www.nature.com/neuro/ 投稿链接: https://mts-nn.nature.com/cgi-bin/main.plex , Sonnet S. Davis,并且可能参与向与神经退行性疾病相关的小胶质细胞状态的转变, Bettina van Lengerich,小胶质细胞功能障碍导致了AD的病理, Giuseppe Astarita, Ju Shi, phagocytosis, Joseph W. Lewcock IssueVolume: 2020-06-08 Abstract: Human genetic data indicate that microglial dysfunction contributes to the pathology of Alzheimers disease (AD)。

Thomas Sandmann,以介导细胞存活、吞噬作用、神经元碎片的处理和脂质代谢,。

a phospholipase-encoding gene expressed in microglia. Although studies in mouse models have implicated specific Trem2-dependent microglial functions in AD,隶属于施普林格自然出版集团, Karin Lin, Yuan Mei,TREM2或PLC2信号的丢失导致这些表型基础的转录失调的共同特征, Laralynne Przybyla。